The SPIDIA project, funded by the FP7 (7th European Research Framework Programme) aimed for standardization and improvement of pre-analytical procedures for in vitro diagnostics by developing necessary guidelines, technologies and tools for practical applications in the area of health and medicine. SPIDIA enabled the developement of several CEN/TS series. These Technical Specification will answer the need to have standardized pre-analytical procedures for e.g. the sample collection, stabilization, transportation, storage and processing integrated in one process. Process will be sample-specific depending on the target for analysis (e.g. RNA, DNA, proteins) to secure dependable and reproducible analytical test results in the clinical/pathological laboratory. SPIDIA has fully met the expectations of the European Commission regarding standardization and improving the pre-analytical procedures for in vitro diagnostic.